The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Chromosome Aberrations in the Blood Lymphocytes of Astronauts after Space Flight
Abstract
Cytogenetic analysis of the lymphocytes of astronauts provides a direct measurement of space radiation damage in vivo, which takes into account individual radiosensitivity and considers the influence of microgravity and other stress conditions. Chromosome exchanges were measured in the blood lymphocytes of eight crew members after their respective space missions, using fluorescence in situ hybridization (FISH) with chromosome painting probes. Significant increases in aberrations were observed after the long-duration missions. The in vivo dose was derived from the frequencies of translocations and total exchanges using calibration curves determined before flight, and the RBE was estimated by comparison with individually measured physical absorbed doses. The values for average RBE were compared to the average quality factor (Q) from direct measurements of the lineal energy spectra using a tissue-equivalent proportional counter (TEPC) and radiation transport codes. The ratio of aberrations identified as complex was slightly higher after flight, which is thought to be an indication of exposure to high-LET radiation. To determine whether the frequency of complex aberrations measured in metaphase spreads after exposure to high-LET radiation was influenced by a cell cycle delay, chromosome damage was analyzed in prematurely condensed chromosome samples collected from two crew members before and after a short-duration mission. The frequency of complex exchanges after flight was higher in prematurely condensed chromosomes than in metaphase cells for one crew member.
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“However, interpretation of these studies is limited by significant individual variability and insufficient statistical power [37,38,39,40].”
From Space Radiation: The number one risk to astronaut health beyond low earth orbit (2014) · cites this paper as [38]
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Cites
Recommendations of the International Commission on Radiological Protection
(1961) · Postgraduate Medical Journal · doi:10.1136/pgmj.37.425.168-b · Cited by 5,868
Recommendations of the International Commission on Radiological Protection
International Commission on Radiological Protection (1959) · Health Physics · doi:10.1097/00004032-195901000-00001 · Cited by 1,706
Rapid Translocation Frequency Analysis in Humans Decades after Exposure to Ionizing Radiation
Lucas, J. N., Awa, A. A., Straume, T., Poggensee, M., Kodama, Y., Nakano, M., Ohtaki, K., Weier, H.-U. G., Pinkel, D., Gray, J. W., et al. (1992) · International Journal of Radiation Biology · doi:10.1080/09553009214551821 · Cited by 434
Durante, M. (1998) · International Journal of Radiation Biology · doi:10.1080/095530098141320 · Cited by 165
Self-citationAnderson, S. (2000) · International Journal of Radiation Biology · doi:10.1080/095530000138989 · Cited by 152
The Radiation Environment in Low-Earth Orbit
Badhwar, G. D. (1997) · Radiation Research · doi:10.2307/3579710 · Cited by 149
Self-citationThe Use of Chromosomal Aberrations in Human Lymphocytes for Biological Dosimetry
Edwards, A. A. (1997) · Radiation Research · doi:10.2307/3579715 · Cited by 131
Finnon, P., Lloyd, D. C., & Edwards, A. A. (1995) · International Journal of Radiation Biology · doi:10.1080/09553009514551391 · Cited by 121
Chromosomal aberrations in blood lymphocytes of astronauts after long-term space flights
HALL, G. O. I. J. C. J. K. (1997) · International Journal of Radiation Biology · doi:10.1080/095530097142889 · Cited by 117
On the scoring of FISH-“painted” chromosome-type exchange aberrations
Savage, J. R. K., & Simpson, P. (1994) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(94)90308-5 · Cited by 108
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Heavy ion carcinogenesis and human space exploration
Durante, M., & Cucinotta, F. A. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2391 · Cited by 578
Self-citationSpace Radiation: The number one risk to astronaut health beyond low earth orbit
Chancellor, J., Scott, G., & Sutton, J. (2014) · Life · doi:10.3390/life4030491 · Cited by 455
ICRP Publication 123: Assessment of Radiation Exposure of Astronauts in Space
Dietze, G., Bartlett, D. T., Cool, D. A., Cucinotta, F. A., Jia, X., McAulay, I. R., Pelliccioni, M., Petrov, V., Reitz, G., & Sato, T. (2013) · Annals of the ICRP · doi:10.1016/j.icrp.2013.05.004 · Cited by 239
Self-citationPhysical and biological organ dosimetry analysis for international space station astronauts
Cucinotta, F. A., Kim, M.-H. Y., Willingham, V., & George, K. A. (2008) · Radiation Research · doi:10.1667/rr1330.1 · Cited by 196
Self-citationInterplay of space radiation and microgravity in DNA damage and DNA damage response
Moreno-Villanueva, M., Wong, M., Lu, T., Zhang, Y., & Wu, H. (2017) · npj Microgravity · doi:10.1038/s41526-017-0019-7 · Cited by 181
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Metadata
- Authors
- George, K., Durante, M., Wu, H., Willingham, V., Badhwar, G., & Cucinotta, F. A.
- Affiliations
- Kelsey-Seybold Clinic (US)
- University of Naples Federico II (IT)
- Johnson Space Center (US)
- Corresponding author
- George, K.
- Venue
- Radiation Research
- Publisher
- Radiation Research Society
- Published
- 2001-12
- Volume
- 156
- Issue
- 6
- Pages
- 731-738
- ISSN
- 0033-7587 (ISSN-L)
- 1938-5404
- OpenAlex
- W2176945815
- Cited by
- 119
- References
- 36
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 4 · 2021: 8 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 5 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 4
- FWCI
- 6.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Radiation Research (publishedVersion)
- PubMed (publishedVersion)
- BioOne Complete (BioOne) (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Health Sciences › Medicine › Physiology (medical) › Spaceflight effects on biology
- Physical Sciences › Physics and Astronomy › Radiation › Radiation Therapy and Dosimetry
- Keywords
- space radiation, astronaut health, blood lymphocytes, chromosomal abnormalities, chromosomal translocation, radiation quality factor, relative biological effectiveness, high-LET radiation, microgravity, cell cycle delay, premature chromosome condensation, long-duration spaceflight
- MeSH terms
- Chromosome Aberrations, Cosmic Radiation, Humans, Lymphocytes, Space Flight
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